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KMID : 0351819940350040443
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Kyunpook University Medical Journal
1994 Volume.35 No. 4 p.443 ~ p.454
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The efficacy of 2% ketoconazole shampoo in treatment of seborrheic dermatitis
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Lee Seok-Jong
Jun Jae-Bok
Kim Do-Won
Chung Sang-Lip
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Abstract
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It is suggested that Pityrosporum ovale may play an important rote in the pathogenesis of seborrheic dermatitis and this organism is sensitive to ketoconazole compound. So the efficacy of 2% ketoconazole shampoo in the treatment of seborrheic dermatitis was tested and was calculated by mean scores of scale, itching and yeast cells.
We interviewed fifty two patients with seborrheic dermatitis about the degree of itching and examined with naked eyes the scale of scalp of them. In a group of the patients, m~~cological study of P. ovcae was also performed by direct smear with 20% KOH solution containng 1 : 1 Parker-ink´s
The results were as follows
As for itching and scale of the scalp, the scores were significantly decreased ac week 2 and week 4 as the duration of treatment prolonged in comparison with that of~ week 0. "I´hc mean yeast cell score at the two points of time was also significantly de~crea:,ed in comparison with Chat of week 0. There was no significant difference in the response from the view of age, sex and duration of seborrheic dermatitis.
It is suggested that the shampooing with ketoconazole 2% shampoo every three other days gave a good result clinically and mycologicalty
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KEYWORD
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seborrheic dermatitis, Pityrosporum ovale, ketoconazole 2% shampoo
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